Molecular Formula | C12H14N2 |
Molar Mass | 186.25 |
Density | 1.077±0.06 g/cm3(Predicted) |
Melting Point | 114-116° |
Boling Point | 386.5±11.0 °C(Predicted) |
Solubility | Chloroform (Slightly), Methanol (Slightly) |
Appearance | Solid |
Color | White to Off-White |
pKa | 14.44±0.10(Predicted) |
Storage Condition | 2-8°C |
In vitro study | Currently, detomidine is only licenced for use in horses. Detomidine is a sedative with analgesic properties. α2-adrenergic agonists produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors, thus inducing a negative feedback response, reducing production of excitatory neurotransmitters. Due to inhibition of the sympathetic nervous system, detomidine also has cardiac and respiratory effects and an antidiuretic action. |
Toxicity | LD50 i.v. in mice: 35 mg/kg (Karjalayne, Kurkela) |